There are three major steps toward the fabrication of a single-digit nanohole: (1) preparing the free-standing thin film by epitaxial deposition and electrochemical etching, (2) making submicron holes by focused ion beam (FIB), and (3) reducing the hole to less than 10 nm by FIB-induced deposition. One specific aim for this paper is to model, simulate, and control the focused ion-beam machining process to fabricate holes that can reach a single-digit nanometer scale on solid-state thin films. Preliminary work has been done on the thin film (30 nm in thickness) preparation, submicron hole fabrication, and ion-beam-induced deposition, and the results are presented.
Issue Section:
Research Papers
1.
Marziali
, A.
, and Akeson
, M.
, 2001, “New DNA Sequencing Methods
,” Annu. Rev. Biomed. Eng.
1523-9829, 3
, pp. 195
–223
.2.
Sauer-Budge
, A. F.
, Nyamwanda
, J. A.
, Lubensky
, D. K.
, and Branton
, D.
, 2003, “Unzipping Kinetics of Double-Stranded DNA in a Nanopore
,” Phys. Rev. Lett.
0031-9007, 90
, pp. 238101
.3.
Li
, J.
, Stein
, D.
, McMullan
, C.
, Branton
, D.
, Aziz
, M. J.
, and Golovchenko
, J. A.
, 2001, “Ion-Beam Sculpting at Nanometer Length Scales
,” Nature (London)
0028-0836, 412
, pp. 166
–169
.4.
Chen
, P.
, Mitsui
, T.
, Farmer
, D. B.
, Golovchenko
, J.
, Gordon
, R. G.
, and Branton
, D.
, 2004, “Atomic Layer Deposition to Fine-Tune the Surface Properties and Diameters of Fabricated Nanopores
,” Nano Lett.
1530-6984, 4
, pp. 1333
–1337
.5.
Storm
, A. J.
, Chen
, J. H.
, Ling
, X. S.
, Zandbergen
, H. W.
, and Dekker
, C.
, 2003, “Fabrication of Solid-State Nanopores With Single-Nanometre Precision
,” Nature Mater.
1476-1122, 2
, pp. 537
–540
.6.
Bustamante
, J. O.
, Hanover
, J. A.
, and Liepins
, A.
, 1995, “The Ion-Channel Behavior of the Nuclear-Pore Complex
,” J. Membr. Biol.
0022-2631, 146
, pp. 239
–251
.7.
Dreiselkelmann
, B.
, 1994, “Translocation of DNA Across Bacterial-Membranes
,” Microbiol. Rev.
0146-0749, 58
, pp. 293
–316
.8.
Luo
, D.
, and Saltzman
, W. M.
, 2000, “Synthetic DNA Delivery Systems
,” Nat. Biotechnol.
1087-0156, 18
, pp. 33
–37
.9.
Felgner
, P. L.
, 1998, “DNA Vaccines
,” Curr. Biol.
0960-9822, 8
, pp. R551
–R553
.10.
Slonkina
, E.
, and Kolomeisky
, A. B.
, 2003, “Polymer Translocation Through a Long Nanopore
,” J. Chem. Phys.
0021-9606, 118
, pp. 7112
–7117
.11.
Deamer
, D. W.
, and Branton
, D.
, 2002, “Characterizing of Nucleic Acids by Nanopore Analysis
,” Acc. Chem. Res.
0001-4842, 35
, pp. 817
–825
.12.
Li
, J.
, Gershow
, M.
, Stein
, D.
, Brandin
, E.
, and Golovchenko
, J. A.
, 2003, “DNA Molecules and Configurations in a Solid-State Nanopore Microscope
,” Nature Mater.
1476-1122, 2
, pp. 611
–615
.13.
Akeson
, M.
, Branton
, D.
, Kasianowicz
, J. J.
, Brandin
, E.
, and Deamer
, D. W.
, 1999, “Microsecond Time-Scale Discrimination Among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments Within Single RNA Molecules
,” Biophys. J.
0006-3495, 77
, pp. 3227
–3233
.14.
Chen
, W.
, and Ahmed
, H.
, 1993, “Fabrication of 5–7 nm Wide Etched Lines in Silicon Using 100 keV Electron-Beam Lithography and Polymethylmethacrylate Resist
,” Appl. Phys. Lett.
0003-6951, 62
, pp. 1499
–1501
.15.
Chen
, C. -M.
, and Peng
, E. -H.
, 2003, “Nanopore Sequencing of Polynucleotides Assisted by a Rotating Electric Field
,” Appl. Phys. Lett.
0003-6951, 82
, pp. 1308
–1310
.16.
Bayley
, H.
, and Cremer
, P. H.
, 2001, “Stochastic Sensors Inspired by Biology
,” Nature (London)
0028-0836, 413
, pp. 226
–230
.17.
Kasianowicz
, J. J.
, Herickson
, S. E.
, Weetall
, H. H.
, and Robertson
, B.
, 2001, “Simultaneous Multianalyte Detection With a Nanometer-Scale Pore
,” Anal. Chem.
0003-2700, 73
, pp. 2268
–2272
.18.
Howorka
, S.
, Cheley
, S.
, and Bayley
, H.
, 2001, “Sequence Specific Detection of Individual DNA Strands Using Engineered Nanopores
,” Nat. Biotechnol.
1087-0156, 19
, pp. 636
–639
.19.
Desai
, T. A.
, Chu
, W. H.
, Tu
, J. K.
, Beattie
, G. M.
, Hayek
, A.
, and Ferrari
, M.
, 1998, “Microfabricated Immunoisolating Biocapsules
,” Biotechnol. Bioeng.
0006-3592, 57
, pp. 118
–120
.20.
Pores Help Nanogate Deliver
, medical materials update, http://www.buscom.com/letters/mmupromo/mmu/mmu.htmlhttp://www.buscom.com/letters/mmupromo/mmu/mmu.html.21.
Burnouf
, T.
, and Radosevich
, M.
, 2003, “Nanofiltration of Plasma-Derived Biopharmaceutical Products
,” Haemophilia
1351-8216, 9
, pp. 24
–37
.22.
Kasianowicz
, J. J.
, Brandin
, E.
, Branton
, D.
, and Deamer
, D. W.
, 1996, “Characterization of Individual Polynucleotide Molecules Using a Membrane Channel
,” Proc. Natl. Acad. Sci. U.S.A.
0027-8424, 93
, pp. 13770
–13773
.23.
Meller
, A.
, Nivon
, L.
, and Branton
, D.
, 2001, “Voltage-Driven DNA Translocations Through a Nanopore
,” Phys. Rev. Lett.
0031-9007, 86
, pp. 3435
–3438
.24.
Henrickson
, S. E.
, Misakian
, M.
, Robertson
, B.
, and Kasianowicz
, J. J.
, 2000, “Driven DNA Transport Into an Asymmetric Nanometer-Scale Pore
,” Phys. Rev. Lett.
0031-9007, 85
, pp. 3057
–3060
.25.
Yong
, C.
, and Pepin
, A.
, 2001, “Nanofabrication: Conventional and Nonconventional Methods
,” Electrophoresis
0173-0835, 22
, pp. 187
–207
.26.
Smith
, H. I.
, and Craighead
, H. G.
, 1990, “Nanofabrication
,” Phys. Today
0031-9228, 43
(2
), pp. 24
–30
.27.
Sze
, S. M.
, 1985, Semiconductor Devices: Physics and Technology
, Wiley
, New York
.28.
Tseng
, A.
, 2004, “Recent Developments in Micromilling Using Focused Ion Beam Technology
,” J. Micromech. Microeng.
0960-1317, 14
, pp. R15
–R34
.29.
Puers
, R.
, and Reyntjens
, S.
, 2000, “Fabrication of Three-Dimensional Microstructures by Focused Ion Beam Direct-Write CVD and Their Application to Hermetic Encapsulations
, Proceedings of the SeSens 2000
, Veldhoven, The Netherlands, pp. 677
–681
.30.
Dubner
, A. D.
, 1991, “The Role of the Ion-Solid Interaction in Ion-Beam-Induced Deposition of Gold
,” J. Appl. Phys.
0021-8979, 70
, pp. 665
–673
.31.
Ralls
, K. S.
, Buhrman
, R. A.
, and Tiberio
, R. C.
, 1989, “Fabrication of Thin-Film Metal Nanobridges
,” Appl. Phys. Lett.
0003-6951, 55
, pp. 2459
–2461
.32.
Apel
, P. Y.
, Korchev
, Y. E.
, Siwy
, Z.
, Spohr
, R.
, and Yoshida
, M.
, 2001, “Diode-Like Single-Ion Track Membrane Prepared by Electro-Stopping
,” Nucl. Instrum. Methods Phys. Res. B
0168-583X, 184
, pp. 337
–346
.33.
Siwy
, Z.
, and Fulinski
, A.
, 2002, “Fabrication of a Synthetic Nanopore Ion Pump
,” Phys. Rev. Lett.
0031-9007, 89
, 198103
.34.
Stein
, D. M.
, McMullan
, C. J.
, Li
, J.
, and Golovchenko
, J. A.
, 2004, “Feedback-Controlled Ion Beam Sculpting Apparatus
,” Rev. Sci. Instrum.
0034-6748, 75
, pp. 900
–905
.35.
Polk
, B.
, Bernard
, M.
, Kasianowicz
, J. J.
, Misakian
, M.
, and Gaitan
, M.
, 2004, “Microelectroplating Silver on Sharp Edges Toward the Fabrication of Solid-State Nanopores
,” J. Electrochem. Soc.
0013-4651, 151
, pp. C559
–C566
.36.
Heng
, J. B.
, Ho
, C.
, Kim
, T.
, Timp
, R.
, Aksimentiev
, A.
, Grinkova
, Y. V.
, Sligar
, S.
, Schulten
, K.
, and Timp
, G.
, 2004, “Sizing DNA Using a Nanometer-Diameter Pore
,” Biophys. J.
0006-3495, 87
, pp. 2905
–2911
.37.
Chen
, P.
, Gu
, J.
, Brandin
, E.
, Kim
, Y. R.
, Wang
, Q.
, and Branton
, D.
, 2004, “Probing Single DNA Molecule Transport Using Fabricated Nanopores
,” Nano Lett.
1530-6984, 4
, pp. 2293
–2298
.38.
Pronko
, P. P.
, Dutta
, S. K.
, Squier
, J.
, Rudd
, J. V.
, Du
, D.
, and Mourou
, G.
, 1995, “Machining of Sub-Micron Holes Using a Femtosecond Laser at 800 nm
,” Opt. Commun.
0030-4018, 114
, pp. 106
–110
.39.
Itoh
, F.
, Shimase
, A.
, and Haraichi
, S.
, 1990, “Two-Dimensional Profile Simulation of Focused Ion-Beam Milling of LSI
,” J. Electrochem. Soc.
0013-4651, 137
, pp. 983
–988
.40.
Biersack
, J. P.
, and Haggmark
, L. G.
, 1980, “A Monte Carlo Computer Program for the Transport of Energetic Ions in Amorphous Targets
,” Nucl. Instrum. Methods
0029-554X, 174
, pp. 257
–269
.41.
Reyntjens
, S.
, and Puers
, R.
, 2000, “Focused Ion Beam Induced Deposition: Fabrication of Three-Dimensional Microstructures and Young’s Modulus of the Deposited Material
,” J. Micromech. Microeng.
0960-1317, 10
, pp. 181
–188
.42.
Edinger
, K.
, and Edinger
, Th.
, 2000, “Modeling of Focused Ion Beam Induced Surface Chemistry
,” J. Vac. Sci. Technol. B
1071-1023, 18
, pp. 3190
–3193
.43.
Maluf
, M.
, and Williams
, K.
, 2004, An Introduction to Microelectromechanical System Engineering
, 2nd ed., Artech House
, Boston, MA
.44.
Vercoutere
, W.
, Winters-Hilt
, S.
, Olsen
, H.
, Deamer
, D. W.
, Haussler
, D.
, and Akeson
, M.
, 2001, “Rapid Discrimination Among Individual DNA Molecules at Single Nucleotide Resolution Using a Nanopore Instrument
,” Nat. Biotechnol.
1087-0156, 19
, pp. 248
–252
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