... the optimal parameter estimators through an exhaustive search in the remaining regions (i.e., focused regions). The focused regions identification method is validated through two case studies in which a model based on Newton’s law of cooling and the Michaelis–Menten model are fitted to two experimental data...

... space for optimal parameter estimators. The method also provides an empirical probability distribution for each parameter, which is valuable for parameter uncertainty assessment. The solution interval method is validated through two case studies in which the Michaelis–Menten model and Fick’s second law...