... deformability can affect blood heat transfer. The heat sink effect in a bifurcated vessel with two asymptotic cases (case 1: deformable and case 2: nondeformable RBCs) is being studied during hyperthermia treatment in a three-dimensional bifurcated vessel, whose wall is being subjected to constant heat flux...

... is modeled as a single-layered, nonlinear, hyperelastic, anisotropic solid, with parameters calibrated from experiment. Linear bifurcation analysis is then performed to predict experimentally measured stability margins. Uncertainties in geometrical parameters and in measured mechanical response were...

... conditions and layer incompatibility. This paper is concerned with the influence of imposed rate (incremental) interface conditions (RICs) on critical loads in soft tissues, within the context of linear bifurcation analysis. Aiming at simplicity, we analyze a model of bilayered isotropic hyperelastic (neo...

... is the implementation of sequential structural and fluid dynamic numerical models to provide a better understanding of stenting procedures in coronary bifurcations. In particular, the realistic geometrical configurations obtained with structural simulations were used to create the fluid domains employed within...

...; a single bifurcation tube; and a simple arterial network with four bifurcations. Soft polyurethane tubes were used and the configuration was based on a realistic human arterial network. The tensile modulus of the material was similar to the elasticity of arteries. A pulsatile flow with ejection time 0.3 s...

... the issue of experimentally validating these calculated deformations, a stereoscopic imaging system utilizing two cameras was constructed to measure model aneurysm displacement in response to pressurization. The three model shapes, consisting of a healthy aorta, an AAA with bifurcation, and an AAA without...

... aortic aneurysm and a carotid artery bifurcation, and one patient specific problem – a Fontan procedure for congenital heart defects. In each case, relevant hemodynamic features are extracted and their uncertainty is quantified. Uncertainty quantification of the hemodynamic simulations is done using...

...Yiemeng Hoi; Bruce A. Wasserman; Edward G. Lakatta; David A. Steinman Controversy exists regarding the suitability of fully developed versus measured inlet velocity profiles for image-based computational fluid dynamics (CFD) studies of carotid bifurcation hemodynamics. Here, we attempt to resolve...

... variables. Here, factor analysis is applied to a set of 14 geometric variables obtained from magnetic resonance images of 50 human carotid bifurcations. Two factors alone were capable of predicting 12 hemodynamic metrics related to shear and near-wall residence time with adjusted squared Pearson’s...

...Umberto Morbiducci; Diego Gallo; Diana Massai; Filippo Consolo; Raffaele Ponzini; Luca Antiga; Cristina Bignardi; Marco A. Deriu; Alberto Redaelli Computational fluid dynamics (CFD) models have become very effective tools for predicting the flow field within the carotid bifurcation...

... hemodynamics of older adult carotid bifurcations has not been elucidated. Image-based computational fluid dynamics models of N = 9 normal, older adult carotid bifurcations were reconstructed from magnetic resonance angiography. Subject-specific hemodynamics were computed by imposing each individual’s inlet...

... speed camera. Integration of the particle locations for a large number of cycles provides the probability distribution of particles passing certain branches within the bifurcating network, and thus, the dispersion of particles in the airways. The results show the different characteristics of flow...

..., in particular, on the fibrous cap vulnerability. Using high-resolution magnetic resonance imaging and histology of an ex vivo human atherosclerotic carotid bifurcation, a patient-specific three-dimensional geometric model, consisting of four tissue components, is generated. The adopted constitutive model...

...Lucy M. O'Keeffe; Gordon Muir; Anna V. Piterina; Tim McGloughlin Atherosclerosis is consistently found in bifurcations and curved segments of the circulatory system, indicating disturbed hemodynamics may participate in disease development. In vivo and in vitro studies have shown that endothelial...

..., for practical purposes, be considered redundant. Image-based computational fluid dynamics simulations were carried out for N = 50 normal carotid bifurcations reconstructed from magnetic resonance imaging. Pairwise Spearman correlation analysis was performed for HWP quantifying wall shear stress magnitudes...

... , employing an experimentally validated computer model. The TB tree was geometrically decomposed into triple-bifurcation units with kinematically adjusted multilevel outlet/inlet conditions. Deposition patterns and maximum concentrations differ greatly between nanoparticles ( 1 ⩽ d p ⩽ 150 nm ) and micron...

... the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based...

... increase centrifugal forces in the bifurcation to produce more vigorous secondary currents; this supports the argument given by Scherer et al. to explain a higher effective axial diffusivity for inspiration than expiration. Greater cross-section mixing due to four secondary vortices on expiration inhibits...

...Toru Hyakutake; Shouko Tominaga; Takeshi Matsumoto; Shinichiro Yanase Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed using the lattice Boltzmann method. A two-dimensional symmetric Y bifurcation...

...A. Comerford; M. J. Plank; T. David It is well known that atherosclerosis occurs at very specific locations throughout the human vasculature, such as arterial bifurcations and bends, all of which are subjected to low wall shear stress. A key player in the pathology of atherosclerosis...