.... , eds., 2004 , Atlas of Heart Disease and Stroke , World Health Organization , Geneva, Switzerland . [2] Simionescu , M. , and Sima , A. , 2012 , “ Morphology of Atherosclerotic Lesions ,” Inflammation and Atherosclerosis , G. Wick and C. Grundtman , eds...

... interaction pulse wave imaging biomechanical modeling pulse wave velocity finite element modeling atherosclerosis Pulse wave imaging (PWI) is an ultrasound-based elastography method that allows indirect quantification of arterial stiffness, via estimation of pulse wave velocity (PWV) [ 1 – 4...

...Ashish Saxena; Eddie Yin Kwee Ng; Tejas Canchi; Jun Jie Tee; Lip Koon Ng Carotid artery stenosis is a form of atherosclerosis, where thrombus formation restricts the passage of blood through the carotid artery leading to irreversible damage in the brain tissue. The presence of stenosis...

... finite element simulations modeling the hyperelastic behavior and resulting stress distribution. The arterial wall composition mimics vessels in atherosclerosis–a complex cardiovascular disease and one of the leading causes of death globally. We formulate the training data to predict the maximum von...

.... , 1983 , “ Carotid Bifurcation Atherosclerosis. Quantitative Correlation of Plaque Localization With Flow Velocity Profiles and Wall Shear Stress ,” Circ. Res. , 53 ( 4 ), pp. 502 – 514 . 10.1161/01.RES.53.4.502 [3] Asakura , T. , and Karino , T. , 1990 , “ Flow Patterns and Spatial...

... Conditions Around Neovessels in Carotid Atherosclerotic Plaque May Promote Intraplaque Hemorrhage ,” Atherosclerosis , 223 ( 2 ), pp. 321 – 326 . 10.1016/j.atherosclerosis.2012.06.015 [17] Underhill , H. R. , Hatsukami , T. S. , Fayad , A. Z. , Fuster , V. , and Yuan , C...

... environment, and the method proposed here may be useful for further investigation of the mechanism of plaque rupture based on in vivo patient data. plaque rupture stress intensity factor fatigue atherosclerosis Atheromatous plaque rupture can often lead to stroke or heart attack, which...

..., 2013; accepted manuscript posted January 18, 2013; published online February 7, 2013. Editor: Victor H. Barocas. 03 10 2012 06 01 2013 18 01 2013 Studies investigating the relation between the focal nature of atherosclerosis and hemodynamic factors are employing increasingly...

... to further validate our findings. intraplaque hemorrhage fluid-structure interactions magnetic resonance imaging plaque wall stress atherosclerosis vulnerability Acute cardiovascular syndromes are often associated with the rupture of atherosclerotic plaque and may occur without any warning...

...Alexey V. Kamenskiy; Jason N. MacTaggart; Iraklis I. Pipinos; Jai Bikhchandani; Yuris A. Dzenis Accurate characterization of carotid artery geometry is vital to our understanding of the pathogenesis of atherosclerosis. Three-dimensional computer reconstructions based on medical imaging are now...

... Grant No. R01 EB004759. Consultations and guidance from Professor Roger Kamm at MIT are happily acknowledged. References 1 Underhill , H. R. , Hatsukami , T. S. , Fayad , Z. A. , Fuster , V. , and Yuan , C. , 2010 , “ MRI of Carotid Atherosclerosis: Clinical...

... by stent deployment. 23 02 2011 21 11 2011 29 12 2011 29 12 2011 bifurcation biomechanics blood vessels haemodynamics internal stresses numerical analysis physiological models stents numerical modeling atherosclerosis stenting procedures coronary bifurcations...

... Shear Stress Region: a Case Report ,” Stroke 38 , pp. 2379 – 2381 . 10.1161/STROKEAHA.107.484766 9 Underhill , H. R. , Hatsukami , T. S. , Fayad , Z. A. , Fuster , V. , and Yuan , C. , 2010 , “ MRI of Carotid Atherosclerosis: Clinical Implications and Future...

... ,” J. Pathol. 0022-3417 , 181 ( 1 ), pp. 93 – 99 . 10.1002/(SICI)1096-9896(199701)181:1<93::AID-PATH696>3.0.CO;2-H Corti , R. , Hutter , R. , Badimon , J. J. , and Fuster , V. , 2004 , “ Evolving Concepts in the Triad of Atherosclerosis, Inflammation and Thrombosis...

... Research Program of the National Institute on Aging, NIH. D.A.S. also acknowledges the support of a Heart & Stroke Foundation Career Investigator Award. Ku , D. N. , Giddens , D. P. , Zarins , C. K. , and Glagov , S. , 1985 , “ Pulsatile Flow and Atherosclerosis in the Human...

... haemodynamics internal stresses numerical analysis physiological models coronary blood flow atherosclerosis computational fluid dynamics shear stress Coronary heart disease (CHD) is the disease that claims the most lives in the U.S., accounting for more than half of all cardiovascular deaths...

... biomedical MRI diseases fracture internal stresses carotid artery atherosclerosis vulnerable plaque stroke MRI plaque rupture fluid-structure interaction Cerebrovascular events, such as stroke, are closely associated with vulnerable carotid plaques ( 1 ). In fact, more than 60% of all...

... mouse model aortic arch atherosclerosis geometric risk factors stereo microscopic imaging computational fluid dynamics wall shear stress Atherosclerotic cardiovascular disease is the leading single cause of mortality worldwide ( 1 ). Over the past decade, the mouse has become an important...

...Lucy M. O'Keeffe; Gordon Muir; Anna V. Piterina; Tim McGloughlin Atherosclerosis is consistently found in bifurcations and curved segments of the circulatory system, indicating disturbed hemodynamics may participate in disease development. In vivo and in vitro studies have shown that endothelial...

... environment. Rather, we suggest that our findings are most applicable to large-scale studies of hemodynamic factors in atherosclerosis, which are more concerned with quantifying overall burdens or identifying patterns of localization of disturbed flow, whatever this vague term may prove to mean precisely...