Understanding the mechanisms of tissue injury in hydrocephalus is important to shed light on the pathophysiology of this neurostructural disorder. To date, most of the finite element models created to study hydrocephalus have been two-dimensional (2D). This may not be adequate as the geometry of the cerebral ventricles is unique. In this study, a three-dimensional (3D) finite element model of the cerebral ventricles during hydrocephalus is presented. Results from this model show that during hydrocephalus, the periventricular regions experience the highest stress, and stress magnitude is approximately 80 times higher than the cerebral mantle. This suggests that functional deficits observed in hydrocephalic patients could therefore be more related to the damage to periventricular white matter. In addition, the stress field simulated in the tissues based on the 3D model was found to be approximately four times lower than on the 2D model.
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e-mail: s.cheng@powmri.edu.au
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Computational Model of the Cerebral Ventricles in Hydrocephalus
Shaokoon Cheng,
Shaokoon Cheng
Prince of Wales Medical Research Institute,
e-mail: s.cheng@powmri.edu.au
University of New South Wales
, Sydney 2031, Australia
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Lynne E. Bilston
Lynne E. Bilston
Prince of Wales Medical Research Institute,
University of New South Wales
, Sydney 2031, Australia
Search for other works by this author on:
Shaokoon Cheng
Prince of Wales Medical Research Institute,
University of New South Wales
, Sydney 2031, Australiae-mail: s.cheng@powmri.edu.au
Lynne E. Bilston
Prince of Wales Medical Research Institute,
University of New South Wales
, Sydney 2031, AustraliaJ Biomech Eng. May 2010, 132(5): 054501 (4 pages)
Published Online: March 24, 2010
Article history
Received:
September 18, 2008
Revised:
May 24, 2009
Posted:
January 14, 2010
Published:
March 24, 2010
Online:
March 24, 2010
Citation
Cheng, S., and Bilston, L. E. (March 24, 2010). "Computational Model of the Cerebral Ventricles in Hydrocephalus." ASME. J Biomech Eng. May 2010; 132(5): 054501. https://doi.org/10.1115/1.4001025
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