Irradiation-induced oxidation of lipid membranes is implicated in diseases and has been harnessed in medical treatments. Irradiation induces the formation of oxidative free radicals, which attack double bonds in the hydrocarbon chains of lipids. Studies of the kinetics of this reaction suggest that the result of the first stage of oxidation is a structural change in the lipid that causes an increase in the area per molecule in a vesicle. Since area changes are directly connected to membrane tension, irradiation-induced oxidation affects the mechanical behavior of a vesicle. Here, we analyze shape changes of axisymmetric vesicles that are under simultaneous influence of adhesion, micropipette aspiration, and irradiation. We study both the equilibrium and kinetics of shape changes and compare our results with experiments. The tension–area relation of a membrane, which is derived by accounting for thermal fluctuations, and the time variation of the mechanical properties due to oxidation play important roles in our analysis. Our model is an example of the coupling of mechanics and chemistry, which is ubiquitous in biology.
Skip Nav Destination
Article navigation
April 2019
Research-Article
Mechanics of Irradiation-Induced Structural Changes in a Lipid Vesicle
Xinyu Liao,
Xinyu Liao
Graduate Group in Applied Mathematics and
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: xinyul@sas.upenn.edu
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: xinyul@sas.upenn.edu
Search for other works by this author on:
Prashant K. Purohit
Prashant K. Purohit
Graduate Group in Applied Mathematics and
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104;
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104;
Department of Mechanical Engineering and
Applied Mechanics,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: purohit@seas.upenn.edu
Applied Mechanics,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: purohit@seas.upenn.edu
Search for other works by this author on:
Xinyu Liao
Graduate Group in Applied Mathematics and
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: xinyul@sas.upenn.edu
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: xinyul@sas.upenn.edu
Prashant K. Purohit
Graduate Group in Applied Mathematics and
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104;
Computational Science,
University of Pennsylvania,
Philadelphia, PA 19104;
Department of Mechanical Engineering and
Applied Mechanics,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: purohit@seas.upenn.edu
Applied Mechanics,
University of Pennsylvania,
Philadelphia, PA 19104
e-mail: purohit@seas.upenn.edu
1Corresponding author.
Contributed by the Applied Mechanics Division of ASME for publication in the JOURNAL OF APPLIED MECHANICS. Manuscript received October 15, 2018; final manuscript received December 23, 2018; published online January 30, 2019. Assoc. Editor: Pedro Reis.
J. Appl. Mech. Apr 2019, 86(4): 041003 (9 pages)
Published Online: January 30, 2019
Article history
Received:
October 15, 2018
Revised:
December 23, 2018
Citation
Liao, X., and Purohit, P. K. (January 30, 2019). "Mechanics of Irradiation-Induced Structural Changes in a Lipid Vesicle." ASME. J. Appl. Mech. April 2019; 86(4): 041003. https://doi.org/10.1115/1.4042429
Download citation file:
279
Views
Get Email Alerts
Cited By
Hamiltonian System-Based Symplectic Framework for Analytical Vibration Analysis of Microplates
J. Appl. Mech (December 2024)
Related Articles
Environmental Barrier Coating Oxidation and Adhesion Strength
J. Eng. Gas Turbines Power (March,2021)
Role of Platinum in Thermal Barrier Coatings Used in Gas Turbine Blade Applications
J. Eng. Gas Turbines Power (February,2010)
Wear Mode Comparison of High-Performance Inconel Alloys
J. Tribol (April,2010)
Related Proceedings Papers
Related Chapters
Surface Analysis and Tools
Tribology of Mechanical Systems: A Guide to Present and Future Technologies
E110opt Fuel Cladding Corrosion under PWR Conditions
Zirconium in the Nuclear Industry: 20th International Symposium
Elastic Constant Used in Continuum-Based Adhesion Models
International Symposium on Information Engineering and Electronic Commerce, 3rd (IEEC 2011)