A self-assembling process has recently been developed that produces tissue engineered articular cartilage constructs of clinically-relevant dimensions with mechanical properties approaching one-third of native values . These constructs, however, are cultured in 10% fetal bovine serum (FBS), which if eliminated, will make them more desirable as an in vitro cartilage replacement towards a translational approach. To this end, this study sought to assess the quality of self-assembled articular cartilage constructs exposed to varying amounts of FBS as well as a serum substitute that has recently been found to induce chondrogenic differentiation and increase cell proliferation .
Defined Medium for the Self-Assembling Process: Enhancing Functionality of Tissue Engineered Articular Cartilage
Revell, CM, & Athanasiou, KA. "Defined Medium for the Self-Assembling Process: Enhancing Functionality of Tissue Engineered Articular Cartilage." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 1015-1016. ASME. https://doi.org/10.1115/SBC2007-176440
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