Whilst blood is the sample most often collected for diagnostic purposes, testing is complicated by the need to purify or concentrate biomarkers prior to detection. While needle/syringe or lancet technology is most often used for bulk sample collection, devices have not yet been developed that selectively capture biomarkers of interest in vivo, simplifying downstream detection requirements. Our group developed the Micropatch Array — a device comprising an array of microprojections which breach the outer layers of the skin to selectively capture biomarkers from the dermis. In this presentation we will describe our emerging data focused on the mechanisms of biomarker capture in vivo, and our investigations into improving the capture efficiency of the devices for important biomarkers.

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