An experimental technique for evaluation of the M-integral in an elastic-plastic material containing multiple defects is proposed by using digital image correlation (DIC). This technique makes direct use of the definition of M by experimentally evaluating the integrand of M at various points along a square contour and determining the integral by numerical integration. The nonlinear Ramberg–Osgood model is used to capture the elastic-plastic behavior such as the elastic-plastic stress and the total strain energy density in terms of the measured displacements by DIC used in an ARAMIS 4M instrument. Compared with the previous experimental method proposed by King and Herrmann (King and Herrmann, 1981, “Nondestructive Evaluation of the J and M Integrals,” ASME J. Appl. Mech., 48, pp. 83–87), the present technique could be suitable to measure the M-integral for the various complicated damages, specimen geometries, loading conditions, and material behaviors. The path-independence or path-dependence of the M-integral is investigated under small-scale and large-scale yielding conditions, respectively. It is found that the values of M are path independent when the contours entirely enclose the nonlinear plastic region near the multiple defects. In contrast, the path-dependence is concluded for an elastic-plastic solid under large-scale yielding condition when the contours have to pass through the plastic zone. This interesting path-dependence of the M-integral is consistent with numerical prediction via the finite element method and theoretical analysis developed in this paper.