In the present work, the Jeffery–Hamel flow problem has been studied using both first- and second-order velocity-slip models, and then compared with the no-slip model. The objectives are to observe the behavior of the flow predicted by the two slip models and to establish criteria for using the two velocity-slip models. The study concentrates on examining the effect of the change in the Knudsen number (Kn) on the velocity profiles, magnitude of slip at the wall, and skin friction coefficient. Assuming that a difference between the two slip models of the order of 10% or less justifies the use of the simple first-order model, the transitional Kn numbers have been found. These Kn numbers depend on the flow direction, being either inflow or outflow. Also, there are three distinct regions that specify where to use each of the no-slip, first-order, and second-order slip models. Further, the reversal of the flow has been investigated as a function of the Kn number and for different , where Re is Reynolds number and is the wall angle. Using the second-order slip models, it is found that as the Kn number increases, reversal occurs at smaller than the 10.31 value at which flow reversal happens in the no-slip model, and increasing the Kn number leads to a reduction in the skin friction coefficient in all cases except when reversal occurs.