A three-phase composite cylinder model is utilized to study the interaction between screw dislocations and nanoscale inclusions. The stress boundary condition at the interface between nanoscale inclusion and the matrix is modified by incorporating surface/interface stress. The explicit solution to this problem is derived by means of the complex variable method. The explicit expressions of image forces exerted on screw dislocations are obtained. The mobility and the equilibrium positions of the dislocation near one of the inclusions are discussed. The results show that, compared to the classical solution (without interface stress), more equilibrium positions of the screw dislocation may be available when the dislocation is close to the nanoscale inclusion due to consider interface stress. Also, the mobility of the dislocation in the matrix will become more complex than the classical case.