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Research Papers

Groove Formation Modeling in Fabricating Hollow Fiber Membrane for Nerve Regeneration

[+] Author and Article Information
Jun Yin, Nicole Coutris

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634

Yong Huang1

Department of Mechanical Engineering, Clemson University, Clemson, SC 29634yongh@clemson.edu

1

Corresponding author.

J. Appl. Mech 78(1), 011017 (Oct 22, 2010) (7 pages) doi:10.1115/1.4002001 History: Received January 15, 2009; Revised February 04, 2010; Posted June 17, 2010; Published October 22, 2010; Online October 22, 2010

Hollow fiber membrane (HFM) is one of the most popular membranes used for different industrial applications. Under some controlled fabrication conditions, axially aligned grooves can be formed on the HFM inner surface during typical immersion precipitation-based phase inversion fabrication processes. Such grooved HFMs are finding promising medical applications for nerve repair and regeneration. For better nerve regeneration performance, the HFM groove morphology should be carefully controlled. Toward this goal, this study has modeled the HFM groove number based on the shrinkage-induced buckling model in HFM fabrication. HFM has been modeled as a three-layer long fiber membrane. The HFM inner layer has been treated as a thin-walled elastic cylindrical shell and buckles due to the shrinkage of the compliant intermediate layer during solidification. The groove geometry, especially the groove number, has been reasonably predicted compared with the experimental measurements. This study has laid a mathematical foundation for HFM circumferential instability modeling, which is of recent interest in membrane fabrication.

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Figures

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Figure 1

Schematic drawing of spinneret and hollow fiber spinning process (S: solvent and NS: nonsolvent)

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Figure 2

HFM with (a) smooth (5), (b) irregular (16), or (c) axially grooved (5) inner surface

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Figure 3

Schematic of the three-layer model before and after instability (three layers are denoted using the subscripts 1, 2, and 3)

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Figure 4

(a) Effect of the Young’s modulus ratio η on the f minimum value (2<k<60) and (b) effect of the groove number on f (η=150 and β=0.05)

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Figure 5

Groove number comparison between the measurements and predictions (η=150 and β=0.05) per fabrication condition: (a) polymer solution flow rate, (b) inner nonsolvent flow rate, and (c) polymer concentration

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