Inaccuracy in the Detection of Molecules Using Two Microcantilever-Based Methods

[+] Author and Article Information
Cheng Luo

Biomedical Engineering and Institute for Micromanufacturing,  Louisiana Tech University, 911 Hergot Avenue, Ruston, LA 71272chengluo@latech.edu

J. Appl. Mech 72(4), 617-619 (Oct 29, 2004) (3 pages) doi:10.1115/1.1938201 History: Received June 21, 2004; Revised October 29, 2004

Based on mass-loading effect on a microcantilever, there are two approaches for sensing the presence of molecules: dynamic and static methods. In this paper, we demonstrate that the two methods actually use the same form of relationships for their sensing purposes and, if the designed adhesion region of a cantilever is only partially occupied by molecules, then neither method can be applied to accurately determine the number of molecules adsorbed.

Copyright © 2005 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 3

Cross-sectional view of a cantilever and the bending configuration under the mass loading of a molecule in the static method

Grahic Jump Location
Figure 2

Relationship between the generalized frequency change and the normalized x coordinate of a molecule

Grahic Jump Location
Figure 1

Cross-sectional view of a cantilever and the geometric meaning of the influence coefficient ai in the dynamic method



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