Even though computer modeling of spacecraft parachutes involves a number of numerical challenges, advanced techniques developed in recent years for fluid-structure interaction (FSI) modeling in general and for parachute FSI modeling specifically have made simulation-based design studies possible. In this paper we focus on such studies for a single main parachute to be used with the Orion spacecraft. Although these large parachutes are typically used in clusters of two or three parachutes, studies for a single parachute can still provide valuable information for performance analysis and design and can be rather extensive. The major challenges in computer modeling of a single spacecraft parachute are the FSI between the air and the parachute canopy and the geometric complexities created by the construction of the parachute from “rings” and “sails” with hundreds of gaps and slits. The Team for Advanced Flow Simulation and Modeling has successfully addressed the computational challenges related to the FSI and geometric complexities, and has also been devising special procedures as needed for specific design parameter studies. In this paper we present parametric studies based on the suspension line length, canopy loading, and the length of the overinflation control line.